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A method is described for the transport of fish resulting in very few or no mortalities during or after this procedure. Commercial salt is added to the water to give a final conentration of 0–5 %, compressed air is bubbled through the water and the fish are kept in 'salt water' after transportation to decrease the incidence of skin infections. 相似文献
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Lyn-Marie Birkholtz Olivier Bastien Gordon Wells Delphine Grando Fourie Joubert Vinod Kasam Marc Zimmermann Philippe Ortet Nicolas Jacq Nadia Saïdani Sylvaine Roy Martin Hofmann-Apitius Vincent Breton Abraham I Louw Eric Maréchal 《Malaria journal》2006,5(1):1-24
The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term, by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data from Plasmodium falciparum, but using also the millions of genomic data from other species. Drug candidates are sought in a chemical space containing the millions of small molecules stored in public and private chemolibraries. Data management should, therefore, be as reliable and versatile as possible. In this context, five aspects of the organization and mining of malaria genomic and post-genomic data were examined: 1) the comparison of protein sequences including compositionally atypical malaria sequences, 2) the high throughput reconstruction of molecular phylogenies, 3) the representation of biological processes, particularly metabolic pathways, 4) the versatile methods to integrate genomic data, biological representations and functional profiling obtained from X-omic experiments after drug treatments and 5) the determination and prediction of protein structures and their molecular docking with drug candidate structures. Recent progress towards a grid-enabled chemogenomic knowledge space is discussed. 相似文献
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Bases and spaces: resources on the web for accessing the draft human genome - II - After publication of the draft 下载免费PDF全文
Colin AM Semple 《Genome biology》2001,2(6):reviews2001.1-reviews20016
The volume of human genome sequence and the variety of web-based tools to access it continue to grow at an impressive rate, but a working knowledge of certain key resources can be sufficient to get the most from your genome. This article provides an update to Genome Biology 2000, 1(4):reviews2001.1-2001.5. 相似文献